Publications
High-resolution label-free 3D mapping of extracellular pH of single living cells.
2019
Zhang Y, Takahashi Y, Hong SP, Liu F, Bednarska J, Goff PS, Novak P, Shevchuk A, Gopal S, Barozzi I, Magnani L, Sakai H, Suguru Y, Fujii T, Erofeev A, Gorelkin P, Majouga A, Weiss DJ, Edwards C, Ivanov AP, Klenerman D, Sviderskaya EV, Edel JB, Korchev Y.
Nat Commun.
A cell topography-based mechanism for ligand discrimination by the T cell receptor
2019
RA Fernandes, KA Ganzinger, JC Tzou, P Jönsson, SF Lee, M Palayret, AM Santos, AR Carr, A Ponjavic, VT Chang, C Macleod, BC Lagerholm, AE Lindsay, O Dushek, A Tilevik, SJ Davis, D Klenerman
Proceedings of the National Academy of Sciences
Imaging rRNA Methylation in Bacteria by MR-FISH
2019
KA Ganzinger, MR Challand, J Spencer, D Klenerman, RT Ranasinghe
Methods Mol Biol
Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates
2019
T Scheidt, U Łapińska, JR Kumita, DR Whiten, D Klenerman, MR Wilson, SIA Cohen, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles, P Arosio
Sci Adv
N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of their Oligomers by the Proteasome Holoenzyme.
2019
Y Ye, D Klenerman, D Finley
J Mol Biol
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression
2019
S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman
Acta Neuropathologica Communications
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.
2019
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman
Nature communications
Citrullination of HP1γ chromodomain affects association with chromatin
2019
M Wiese, AJ Bannister, S Basu, W Boucher, K Wohlfahrt, MA Christophorou, ML Nielsen, D Klenerman, ED Laue, T Kouzarides
Epigenetics & Chromatin
Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species
2019
JC Sang, J-E Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, TPJ Knowles, D Klenerman
Chemical Science
Spectrally-Resolved Photodynamics Of Individual Emitters In Large-Area Monolayers Of Hexagonal-Boron Nitride.
2019
HL Stern, R Wang, Y Fan, R Mizuta, JC Stewart, L-M Needham, TD Roberts, R Wai, NS Ginsberg, D Klenerman, S Hofmann, SF Lee
ACS nano
Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.
2019
T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse
ACS Chem Neurosci
Filamentous aggregates are fragmented by the proteasome holoenzyme
2019
R Cliffe, JC Sang, F Kundel, D Finley, D Klenerman, Y Ye
Cell Rep
Simple and ultrafast resonance frequency and dissipation shift measurements using a fixed frequency drive
2019
A Guha, N Sandström, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh
Sensors and Actuators B: Chemical
Picomolar concentrations of oligomeric alpha synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis
2019
CD Hughes, ML Choi, M Ryten, L Hopkins, A Drews, JA Botía, M Iljina, M Rodrigues, SA Gagliano, S Gandhi, C Bryant, D Klenerman
Acta Neuropathologica
Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease
2019
S De, D Klenerman
Biochimica et biophysica acta. Proteins and proteomics