Referenced Single-Molecule Measurements Differentiate between GPCR Oligomerization States


SL Latty, JH Felce, L Weimann, SF Lee, SJ Davis, D Klenerman

Biophysical journal

The 2015 super-resolution microscopy roadmap


SW Hell, SJ Sahl, M Bates, X Zhuang, R Heintzmann, MJ Booth, J Bewersdorf, G Shtengel, H Hess, P Tinnefeld, A Honigmann, S Jakobs, I Testa, L Cognet, B Lounis, H Ewers, SJ Davis, C Eggeling, D Klenerman, KI Willig, G Vicidomini, M Castello, A Diaspro, T Cordes

Journal of Physics D: Applied Physics

Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers.


MH Horrocks, L Tosatto, AJ Dear, GA Garcia, M Iljina, N Cremades, M Dalla Serra, TPJ Knowles, CM Dobson, D Klenerman

Analytical chemistry

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation


SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, EJ De-Genst, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades

Proceedings of the National Academy of Sciences of the United States of America

On-demand delivery of single DNA molecules using nanopipets


AP Ivanov, P Actis, P Jönsson, D Klenerman, Y Korchev, JB Edel

ACS Nano

Lipid peroxidation is essential for α-synuclein-induced cell death


PR Angelova, MH Horrocks, D Klenerman, S Gandhi, AY Abramov, MS Shchepinov

Journal of Neurochemistry

SICM-Based Nanodelivery System for Local TRPV1 Stimulation


A Lopez-Cordoba, P Joensson, B Babakinejad, P Actis, P Novak, T Yasufumi, A Shevchuck, U Anand, P Anand, A Drews, A Ferrer-Montiel, D Klenerman, Y Korchev

Biophysical Journal

Lipid peroxidation is essential for alpha-synuclein-induced cell death


PR Angelova, MH Horrocks, D Klenerman, S Gandhi, AY Abramov, MS Shchepinov

J Neurochem

Single-molecule FRET reveals hidden complexity in a protein energy landscape.


M Tsytlonok, SM Ibrahim, PJE Rowling, W Xu, MJ Ruedas-Rama, A Orte, D Klenerman, LS Itzhaki

Structure (London, England : 1993)

Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus.


DJ Whitcomb, EL Hogg, P Regan, T Piers, P Narayan, G Whitehead, BL Winters, D-H Kim, E Kim, P St George-Hyslop, D Klenerman, GL Collingridge, J Jo, K Cho

Scientific reports

Virtual-'light-sheet' single-molecule localisation microscopy enables quantitative optical sectioning for super-resolution imaging


M Palayret, H Armes, S Basu, AT Watson, A Herbert, D Lando, TJ Etheridge, U Endesfelder, M Heilemann, E Laue, AM Carr, D Klenerman, SF Lee

PLoS One

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers.


SL Shammas, GA Garcia, S Kumar, M Kjaergaard, MH Horrocks, N Shivji, E Mandelkow, TPJ Knowles, E Mandelkow, D Klenerman

Nature communications

Aggregated α-synuclein and complex I deficiency: Exploration of their relationship in differentiated neurons


AK Reeve, MHR Ludtmann, PR Angelova, EM Simcox, MH Horrocks, D Klenerman, S Gandhi, DM Turnbull, AY Abramov

Cell death & disease

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants


L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, N Cremades, CM Dobson, D Klenerman

Sci Rep

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