Publications
Referenced Single-Molecule Measurements Differentiate between GPCR Oligomerization States
2015
SL Latty, JH Felce, L Weimann, SF Lee, SJ Davis, D Klenerman
Biophysical journal
The 2015 super-resolution microscopy roadmap
2015
SW Hell, SJ Sahl, M Bates, X Zhuang, R Heintzmann, MJ Booth, J Bewersdorf, G Shtengel, H Hess, P Tinnefeld, A Honigmann, S Jakobs, I Testa, L Cognet, B Lounis, H Ewers, SJ Davis, C Eggeling, D Klenerman, KI Willig, G Vicidomini, M Castello, A Diaspro, T Cordes
Journal of Physics D: Applied Physics
Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers.
2015
MH Horrocks, L Tosatto, AJ Dear, GA Garcia, M Iljina, N Cremades, M Dalla Serra, TPJ Knowles, CM Dobson, D Klenerman
Analytical chemistry
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
2015
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, EJ De-Genst, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
Proceedings of the National Academy of Sciences of the United States of America
On-demand delivery of single DNA molecules using nanopipets
2015
AP Ivanov, P Actis, P Jönsson, D Klenerman, Y Korchev, JB Edel
ACS Nano
Lipid peroxidation is essential for α-synuclein-induced cell death
2015
PR Angelova, MH Horrocks, D Klenerman, S Gandhi, AY Abramov, MS Shchepinov
Journal of Neurochemistry
SICM-Based Nanodelivery System for Local TRPV1 Stimulation
2015
A Lopez-Cordoba, P Joensson, B Babakinejad, P Actis, P Novak, T Yasufumi, A Shevchuck, U Anand, P Anand, A Drews, A Ferrer-Montiel, D Klenerman, Y Korchev
Biophysical Journal
Lipid peroxidation is essential for alpha-synuclein-induced cell death
2015
PR Angelova, MH Horrocks, D Klenerman, S Gandhi, AY Abramov, MS Shchepinov
J Neurochem
Single-molecule FRET reveals hidden complexity in a protein energy landscape.
2015
M Tsytlonok, SM Ibrahim, PJE Rowling, W Xu, MJ Ruedas-Rama, A Orte, D Klenerman, LS Itzhaki
Structure (London, England : 1993)
Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus.
2015
DJ Whitcomb, EL Hogg, P Regan, T Piers, P Narayan, G Whitehead, BL Winters, D-H Kim, E Kim, P St George-Hyslop, D Klenerman, GL Collingridge, J Jo, K Cho
Scientific reports
Virtual-'light-sheet' single-molecule localisation microscopy enables quantitative optical sectioning for super-resolution imaging
2015
M Palayret, H Armes, S Basu, AT Watson, A Herbert, D Lando, TJ Etheridge, U Endesfelder, M Heilemann, E Laue, AM Carr, D Klenerman, SF Lee
PLoS One
A mechanistic model of tau amyloid aggregation based on direct observation of oligomers.
2015
SL Shammas, GA Garcia, S Kumar, M Kjaergaard, MH Horrocks, N Shivji, E Mandelkow, TPJ Knowles, E Mandelkow, D Klenerman
Nature communications
Aggregated α-synuclein and complex I deficiency: Exploration of their relationship in differentiated neurons
2015
AK Reeve, MHR Ludtmann, PR Angelova, EM Simcox, MH Horrocks, D Klenerman, S Gandhi, DM Turnbull, AY Abramov
Cell death & disease
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants
2015
L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, N Cremades, CM Dobson, D Klenerman
Sci Rep