Publications

Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies.

2020

Brain Commun.

Sanderson JB, De S, Jiang H, Rovere M, Jin M, Zaccagnini L, Hays Watson A, De Boni L, Lagomarsino VN, Young-Pearse TL, Liu X, Pochapsky TC, Hyman BT, Dickson DW, Klenerman D, Selkoe DJ, Bartels T.

Digital Sensing and Molecular Computation by an Enzyme-Free DNA Circuit.

2020

ACS Nano.

Arter WE, Yusim Y, Peter Q, Taylor CG, Klenerman D, Keyser UF, Knowles TPJ

The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.

2020

Curr Opin Neurobiol.

Meisl G, Knowles TP, Klenerman D.

The Costs of Close Contacts: Visualizing the Energy Landscape of Cell Contacts at the Nanoscale.

2020

Biophys J.

Kulenkampff K, Lippert AH, McColl J, Santos AM, Ponjavic A, Jenkins E, Humphrey J, Winkel A, Franze K, Lee SF, Davis SJ, Klenerman D.

Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death.

2020

Commun Biol.

Hughes C, Choi ML, Yi JH, Kim SC, Drews A, George-Hyslop PS, Bryant C, Gandhi S, Cho K, Klenerman D.

MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling.

2020

Structure

Moncrieffe MC, Bollschweiler D, Li B, Penczek PA, Hopkins L, Bryant CE, Klenerman D, Gay NJ.

A General in Vitro Assay for Studying Enzymatic Activities of the Ubiquitin System.

2020

Biochemistry

Zuo Y, Chong BK, Jiang K, Finley D, Klenerman D, Ye Y.

High-resolution label-free 3D mapping of extracellular pH of single living cells.

2019

Nat Commun.

Zhang Y, Takahashi Y, Hong SP, Liu F, Bednarska J, Goff PS, Novak P, Shevchuk A, Gopal S, Barozzi I, Magnani L, Sakai H, Suguru Y, Fujii T, Erofeev A, Gorelkin P, Majouga A, Weiss DJ, Edwards C, Ivanov AP, Klenerman D, Sviderskaya EV, Edel JB, Korchev Y.

α-Synuclein strains target distinct brain regions and cell types.

2020

Nat Neurosci.

Lau A, So RWL, Lau HHC, Sang JC, Ruiz-Riquelme A, Fleck SC, Stuart E, Menon S, Visanji NP, Meisl G, Faidi R, Marano MM, Schmitt-Ulms C, Wang Z, Fraser PE, Tandon A, Hyman BT, Wille H, Ingelsson M, Klenerman D, Watts JC.

N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme

2020

J Mol Biol.

Ye Y, Klenerman D, Finley D.

A cell topography-based mechanism for ligand discrimination by the T cell receptor

2019

Proceedings of the National Academy of Sciences

RA Fernandes, KA Ganzinger, JC Tzou, P Jönsson, SF Lee, M Palayret, AM Santos, AR Carr, A Ponjavic, VT Chang, C Macleod, BC Lagerholm, AE Lindsay, O Dushek, A Tilevik, SJ Davis, D Klenerman

Imaging rRNA Methylation in Bacteria by MR-FISH

2019

Methods Mol Biol

KA Ganzinger, MR Challand, J Spencer, D Klenerman, RT Ranasinghe

Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

2019

Sci Adv

T Scheidt, U Łapińska, JR Kumita, DR Whiten, D Klenerman, MR Wilson, SIA Cohen, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles, P Arosio

N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of their Oligomers by the Proteasome Holoenzyme.

2019

J Mol Biol

Y Ye, D Klenerman, D Finley

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression

2019

Acta Neuropathologica Communications

S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.

2019

Nature communications

S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman

Citrullination of HP1γ chromodomain affects association with chromatin

2019

Epigenetics & Chromatin

M Wiese, AJ Bannister, S Basu, W Boucher, K Wohlfahrt, MA Christophorou, ML Nielsen, D Klenerman, ED Laue, T Kouzarides

Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species

2019

Chemical Science

JC Sang, J-E Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, TPJ Knowles, D Klenerman

Spectrally-Resolved Photodynamics Of Individual Emitters In Large-Area Monolayers Of Hexagonal-Boron Nitride.

2019

ACS nano

HL Stern, R Wang, Y Fan, R Mizuta, JC Stewart, L-M Needham, TD Roberts, R Wai, NS Ginsberg, D Klenerman, S Hofmann, SF Lee

Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.

2019

ACS Chem Neurosci

T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse

Filamentous aggregates are fragmented by the proteasome holoenzyme

2019

Cell Rep

R Cliffe, JC Sang, F Kundel, D Finley, D Klenerman, Y Ye

Simple and ultrafast resonance frequency and dissipation shift measurements using a fixed frequency drive

2019

Sensors and Actuators B: Chemical

A Guha, N Sandström, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh

Picomolar concentrations of oligomeric alpha synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis

2019

Acta Neuropathologica

CD Hughes, ML Choi, M Ryten, L Hopkins, A Drews, JA Botía, M Iljina, M Rodrigues, SA Gagliano, S Gandhi, C Bryant, D Klenerman

Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease

2019

Biochimica et biophysica acta. Proteins and proteomics

S De, D Klenerman

Oligomer Diversity during the Aggregation of the Repeat Region of Tau.

2018

ACS Chemical Neuroscience

M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, D Klenerman

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