Publications
Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies.
2020
Brain Commun.
Sanderson JB, De S, Jiang H, Rovere M, Jin M, Zaccagnini L, Hays Watson A, De Boni L, Lagomarsino VN, Young-Pearse TL, Liu X, Pochapsky TC, Hyman BT, Dickson DW, Klenerman D, Selkoe DJ, Bartels T.
Digital Sensing and Molecular Computation by an Enzyme-Free DNA Circuit.
2020
ACS Nano.
Arter WE, Yusim Y, Peter Q, Taylor CG, Klenerman D, Keyser UF, Knowles TPJ
The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.
2020
Curr Opin Neurobiol.
Meisl G, Knowles TP, Klenerman D.
The Costs of Close Contacts: Visualizing the Energy Landscape of Cell Contacts at the Nanoscale.
2020
Biophys J.
Kulenkampff K, Lippert AH, McColl J, Santos AM, Ponjavic A, Jenkins E, Humphrey J, Winkel A, Franze K, Lee SF, Davis SJ, Klenerman D.
Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death.
2020
Commun Biol.
Hughes C, Choi ML, Yi JH, Kim SC, Drews A, George-Hyslop PS, Bryant C, Gandhi S, Cho K, Klenerman D.
MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling.
2020
Structure
Moncrieffe MC, Bollschweiler D, Li B, Penczek PA, Hopkins L, Bryant CE, Klenerman D, Gay NJ.
A General in Vitro Assay for Studying Enzymatic Activities of the Ubiquitin System.
2020
Biochemistry
Zuo Y, Chong BK, Jiang K, Finley D, Klenerman D, Ye Y.
High-resolution label-free 3D mapping of extracellular pH of single living cells.
2019
Nat Commun.
Zhang Y, Takahashi Y, Hong SP, Liu F, Bednarska J, Goff PS, Novak P, Shevchuk A, Gopal S, Barozzi I, Magnani L, Sakai H, Suguru Y, Fujii T, Erofeev A, Gorelkin P, Majouga A, Weiss DJ, Edwards C, Ivanov AP, Klenerman D, Sviderskaya EV, Edel JB, Korchev Y.
α-Synuclein strains target distinct brain regions and cell types.
2020
Nat Neurosci.
Lau A, So RWL, Lau HHC, Sang JC, Ruiz-Riquelme A, Fleck SC, Stuart E, Menon S, Visanji NP, Meisl G, Faidi R, Marano MM, Schmitt-Ulms C, Wang Z, Fraser PE, Tandon A, Hyman BT, Wille H, Ingelsson M, Klenerman D, Watts JC.
N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme
2020
J Mol Biol.
Ye Y, Klenerman D, Finley D.
A cell topography-based mechanism for ligand discrimination by the T cell receptor
2019
Proceedings of the National Academy of Sciences
RA Fernandes, KA Ganzinger, JC Tzou, P Jönsson, SF Lee, M Palayret, AM Santos, AR Carr, A Ponjavic, VT Chang, C Macleod, BC Lagerholm, AE Lindsay, O Dushek, A Tilevik, SJ Davis, D Klenerman
Imaging rRNA Methylation in Bacteria by MR-FISH
2019
Methods Mol Biol
KA Ganzinger, MR Challand, J Spencer, D Klenerman, RT Ranasinghe
Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates
2019
Sci Adv
T Scheidt, U Łapińska, JR Kumita, DR Whiten, D Klenerman, MR Wilson, SIA Cohen, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles, P Arosio
N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of their Oligomers by the Proteasome Holoenzyme.
2019
J Mol Biol
Y Ye, D Klenerman, D Finley
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression
2019
Acta Neuropathologica Communications
S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.
2019
Nature communications
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman
Citrullination of HP1γ chromodomain affects association with chromatin
2019
Epigenetics & Chromatin
M Wiese, AJ Bannister, S Basu, W Boucher, K Wohlfahrt, MA Christophorou, ML Nielsen, D Klenerman, ED Laue, T Kouzarides
Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species
2019
Chemical Science
JC Sang, J-E Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, TPJ Knowles, D Klenerman
Spectrally-Resolved Photodynamics Of Individual Emitters In Large-Area Monolayers Of Hexagonal-Boron Nitride.
2019
ACS nano
HL Stern, R Wang, Y Fan, R Mizuta, JC Stewart, L-M Needham, TD Roberts, R Wai, NS Ginsberg, D Klenerman, S Hofmann, SF Lee
Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.
2019
ACS Chem Neurosci
T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse
Filamentous aggregates are fragmented by the proteasome holoenzyme
2019
Cell Rep
R Cliffe, JC Sang, F Kundel, D Finley, D Klenerman, Y Ye
Simple and ultrafast resonance frequency and dissipation shift measurements using a fixed frequency drive
2019
Sensors and Actuators B: Chemical
A Guha, N Sandström, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh
Picomolar concentrations of oligomeric alpha synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis
2019
Acta Neuropathologica
CD Hughes, ML Choi, M Ryten, L Hopkins, A Drews, JA Botía, M Iljina, M Rodrigues, SA Gagliano, S Gandhi, C Bryant, D Klenerman
Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease
2019
Biochimica et biophysica acta. Proteins and proteomics
S De, D Klenerman
Oligomer Diversity during the Aggregation of the Repeat Region of Tau.
2018
ACS Chemical Neuroscience
M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, D Klenerman