Publications

A cell topography-based mechanism for ligand discrimination by the T cell receptor

2019

RA Fernandes, KA Ganzinger, JC Tzou, P Jönsson, SF Lee, M Palayret, AM Santos, AR Carr, A Ponjavic, VT Chang, C Macleod, BC Lagerholm, AE Lindsay, O Dushek, A Tilevik, SJ Davis, D Klenerman

Proceedings of the National Academy of Sciences

Imaging rRNA Methylation in Bacteria by MR-FISH

2019

KA Ganzinger, MR Challand, J Spencer, D Klenerman, RT Ranasinghe

Methods Mol Biol

Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

2019

T Scheidt, U Łapińska, JR Kumita, DR Whiten, D Klenerman, MR Wilson, SIA Cohen, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles, P Arosio

Sci Adv

N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of their Oligomers by the Proteasome Holoenzyme.

2019

Y Ye, D Klenerman, D Finley

J Mol Biol

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression

2019

S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman

Acta Neuropathologica Communications

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.

2019

S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman

Nature communications

Citrullination of HP1γ chromodomain affects association with chromatin

2019

M Wiese, AJ Bannister, S Basu, W Boucher, K Wohlfahrt, MA Christophorou, ML Nielsen, D Klenerman, ED Laue, T Kouzarides

Epigenetics & Chromatin

Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species

2019

JC Sang, J-E Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, TPJ Knowles, D Klenerman

Chemical Science

Spectrally-Resolved Photodynamics Of Individual Emitters In Large-Area Monolayers Of Hexagonal-Boron Nitride.

2019

HL Stern, R Wang, Y Fan, R Mizuta, JC Stewart, L-M Needham, TD Roberts, R Wai, NS Ginsberg, D Klenerman, S Hofmann, SF Lee

ACS nano

Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.

2019

T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse

ACS Chem Neurosci

Filamentous aggregates are fragmented by the proteasome holoenzyme

2019

R Cliffe, JC Sang, F Kundel, D Finley, D Klenerman, Y Ye

Cell Rep

Simple and ultrafast resonance frequency and dissipation shift measurements using a fixed frequency drive

2019

A Guha, N Sandström, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh

Sensors and Actuators B: Chemical

Picomolar concentrations of oligomeric alpha synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis

2019

CD Hughes, ML Choi, M Ryten, L Hopkins, A Drews, JA Botía, M Iljina, M Rodrigues, SA Gagliano, S Gandhi, C Bryant, D Klenerman

Acta Neuropathologica

Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease

2019

S De, D Klenerman

Biochimica et biophysica acta. Proteins and proteomics

Oligomer Diversity during the Aggregation of the Repeat Region of Tau.

2018

M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, D Klenerman

ACS Chemical Neuroscience

Mapping Surface Hydrophobicity of alpha-Synuclein Oligomers at the Nanoscale

2018

J-E Lee, JC Sang, M Rodrigues, AR Carr, MH Horrocks, S De, MN Bongiovanni, P Flagmeier, CM Dobson, DJ Wales, SF Lee, D Klenerman

Nano Letters

alpha-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease

2018

MHR Ludtmann, PR Angelova, MH Horrocks, ML Choi, M Rodrigues, AY Baev, AV Berezhnov, Z Yao, D Little, B Banushi, AS Al-Menhali, RT Ranasinghe, DR Whiten, R Yapom, KS Dolt, MJ Devine, P Gissen, T Kunath, M Jaganjac, EV Pavlov, D Klenerman, AY Abramov, S Gandhi

Nat Commun

Quantifying Co-Oligomer Formation by alpha-Synuclein

2018

M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, TCT Michaels, D Frenkel, CM Dobson, TPJ Knowles, D Klenerman

ACS Nano

Filamentous aggregates are fragmented by the proteasome holoenzyme

2018

R Cliffe, J Sang, F Kundel, D Finley, D Klenerman, Y Ye

Cell Reports

Sensitive light-sheet microscopy in multiwell plates using an AFM cantilever

2018

A Ponjavic, Y Ye, E Laue, SF Lee, D Klenerman

Biomedical Optics Express

Characterisation of particle-surface interactions via anharmonic acoustic transduction

2018

C da Silva Granja, N Sandström, I Efimov, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh

Sensors and Actuators B: Chemical

Correction to: Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis

2018

CD Hughes, ML Choi, M Ryten, L Hopkins, A Drews, JA Botía, M Iljina, M Rodrigues, SA Gagliano, S Gandhi, C Bryant, D Klenerman

Acta Neuropathologica

Direct observation of murine prion protein replication in vitro

2018

JC Sang, G Meisl, AM Thackray, L Hong, A Ponjavic, TPJ Knowles, R Bujdoso, D Klenerman

Journal of the American Chemical Society

Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells

2018

DR Whiten, Y Zuo, L Calo, M-L Choi, S De, P Flagmeier, DC Wirthensohn, F Kundel, RT Ranasinghe, SE Sanchez, D Athauda, SF Lee, CM Dobson, S Gandhi, M-G Spillantini, D Klenerman, MH Horrocks

Chembiochem

Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution.

2018

CG Taylor, G Meisl, MH Horrocks, H Zetterberg, TPJ Knowles, D Klenerman

Anal Chem

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