Publications

Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies.

2020

Sanderson JB, De S, Jiang H, Rovere M, Jin M, Zaccagnini L, Hays Watson A, De Boni L, Lagomarsino VN, Young-Pearse TL, Liu X, Pochapsky TC, Hyman BT, Dickson DW, Klenerman D, Selkoe DJ, Bartels T.

Brain Commun.

Digital Sensing and Molecular Computation by an Enzyme-Free DNA Circuit.

2020

Arter WE, Yusim Y, Peter Q, Taylor CG, Klenerman D, Keyser UF, Knowles TPJ

ACS Nano.

The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.

2020

Meisl G, Knowles TP, Klenerman D.

Curr Opin Neurobiol.

The Costs of Close Contacts: Visualizing the Energy Landscape of Cell Contacts at the Nanoscale.

2020

Kulenkampff K, Lippert AH, McColl J, Santos AM, Ponjavic A, Jenkins E, Humphrey J, Winkel A, Franze K, Lee SF, Davis SJ, Klenerman D.

Biophys J.

Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death.

2020

Hughes C, Choi ML, Yi JH, Kim SC, Drews A, George-Hyslop PS, Bryant C, Gandhi S, Cho K, Klenerman D.

Commun Biol.

MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling.

2020

Moncrieffe MC, Bollschweiler D, Li B, Penczek PA, Hopkins L, Bryant CE, Klenerman D, Gay NJ.

Structure

A General in Vitro Assay for Studying Enzymatic Activities of the Ubiquitin System.

2020

Zuo Y, Chong BK, Jiang K, Finley D, Klenerman D, Ye Y.

Biochemistry

High-resolution label-free 3D mapping of extracellular pH of single living cells.

2019

Zhang Y, Takahashi Y, Hong SP, Liu F, Bednarska J, Goff PS, Novak P, Shevchuk A, Gopal S, Barozzi I, Magnani L, Sakai H, Suguru Y, Fujii T, Erofeev A, Gorelkin P, Majouga A, Weiss DJ, Edwards C, Ivanov AP, Klenerman D, Sviderskaya EV, Edel JB, Korchev Y.

Nat Commun.

α-Synuclein strains target distinct brain regions and cell types.

2020

Lau A, So RWL, Lau HHC, Sang JC, Ruiz-Riquelme A, Fleck SC, Stuart E, Menon S, Visanji NP, Meisl G, Faidi R, Marano MM, Schmitt-Ulms C, Wang Z, Fraser PE, Tandon A, Hyman BT, Wille H, Ingelsson M, Klenerman D, Watts JC.

Nat Neurosci.

N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme

2020

Ye Y, Klenerman D, Finley D.

J Mol Biol.

A cell topography-based mechanism for ligand discrimination by the T cell receptor

2019

RA Fernandes, KA Ganzinger, JC Tzou, P Jönsson, SF Lee, M Palayret, AM Santos, AR Carr, A Ponjavic, VT Chang, C Macleod, BC Lagerholm, AE Lindsay, O Dushek, A Tilevik, SJ Davis, D Klenerman

Proceedings of the National Academy of Sciences

Imaging rRNA Methylation in Bacteria by MR-FISH

2019

KA Ganzinger, MR Challand, J Spencer, D Klenerman, RT Ranasinghe

Methods Mol Biol

Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

2019

T Scheidt, U Łapińska, JR Kumita, DR Whiten, D Klenerman, MR Wilson, SIA Cohen, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles, P Arosio

Sci Adv

N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of their Oligomers by the Proteasome Holoenzyme.

2019

Y Ye, D Klenerman, D Finley

J Mol Biol

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression

2019

S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman

Acta Neuropathologica Communications

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.

2019

S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman

Nature communications

Citrullination of HP1γ chromodomain affects association with chromatin

2019

M Wiese, AJ Bannister, S Basu, W Boucher, K Wohlfahrt, MA Christophorou, ML Nielsen, D Klenerman, ED Laue, T Kouzarides

Epigenetics & Chromatin

Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species

2019

JC Sang, J-E Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, TPJ Knowles, D Klenerman

Chemical Science

Spectrally-Resolved Photodynamics Of Individual Emitters In Large-Area Monolayers Of Hexagonal-Boron Nitride.

2019

HL Stern, R Wang, Y Fan, R Mizuta, JC Stewart, L-M Needham, TD Roberts, R Wai, NS Ginsberg, D Klenerman, S Hofmann, SF Lee

ACS nano

Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.

2019

T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse

ACS Chem Neurosci

Filamentous aggregates are fragmented by the proteasome holoenzyme

2019

R Cliffe, JC Sang, F Kundel, D Finley, D Klenerman, Y Ye

Cell Rep

Simple and ultrafast resonance frequency and dissipation shift measurements using a fixed frequency drive

2019

A Guha, N Sandström, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh

Sensors and Actuators B: Chemical

Picomolar concentrations of oligomeric alpha synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis

2019

CD Hughes, ML Choi, M Ryten, L Hopkins, A Drews, JA Botía, M Iljina, M Rodrigues, SA Gagliano, S Gandhi, C Bryant, D Klenerman

Acta Neuropathologica

Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease

2019

S De, D Klenerman

Biochimica et biophysica acta. Proteins and proteomics

Oligomer Diversity during the Aggregation of the Repeat Region of Tau.

2018

M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, D Klenerman

ACS Chemical Neuroscience

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