PRINCIPAL INVESTIGATOR
Professor Sir David Klenerman
David Klenerman's research is focused on developing and applying biophysical methods to biological and biomedical problems. His work using fluorescence and scanning probe microscopy has provided new insights into a variety of biomolecular complexes as well as the processes of protein folding and misfolding. David has also developed techniques to image individual protein complexes on the surface of living cells to follow the processes occurring as the adaptive immune response is triggered. These methods are now being used to study neurodegenerative disease.
David is a research fellow at the Royal Society, a fellow at the Academy of Medical Sciences and a fellow at Christ's College.
POSTDOCTORAL RESEARCHERS
Dr Debasis Banik
Debasis is a Marie Curie postdoctoral fellow in the Klenerman group and currently working on developing an imaging-based ultrasensitive assay to monitor the early events of T cell-tumour interaction and identify the protein re-organization at interface. In his previous role at the Vanderbilt Univ...
Dr Georg Meisl
Georg is a postdoctoral researcher developing mathematical models of protein aggregation and neurodegenerative disease. He received his Msc in Chemistry and his PhD in biophysical Chemistry from the University of Cambridge. Following this, he was a Ramon Jenkins Research Fellow at Sidney Sussex C...
Dr Shekhar Kedia
Shekhar is a postdoctoral researcher in Prof. Klenerman's group. He completed his PhD in Neuroscience (2020) from the Indian Institute of Science (IISc), Bangalore, India and was awarded a gold medal for his thesis. His research interests lie in understanding the nanoscale triggers of neurodegene...
Dr Yunzhao Wu
I’m a Ph.D. student working on elucidating the mechanisms of p53 aggregation in cancer with super-resolution imaging. I graduated from Shanghai Jiao Tong University in 2017 and obtained my master’s degree at the University of Tokyo in 2019. In my spare time, I enjoy cooking Chinese food (especial...
Dr Jason Sang
Jason finished his undergraduate studies in Taiwan and subsequently received his PhD from the University of Cambridge (under the supervision of Professor David Klenerman), studying the mechanism of prion-like aggregation in vitro. He applied single-molecule fluorescence techniques to directly obs...
Dr Yu Zhang
I am a PhD student working on developing advanced single molecule techniques towards in-depth research of the molecular basis of major neurogenerative diseases. Before moving to Cambridge, where I work under the joint supervision of Prof. David Klenerman and Dr Steven Lee, I studied nanomaterials...
Dr Ziwei Zhang
I am a PhD student on a joint-project between the Klenerman’s group and the Laue group in the Department of Biochemistry at Cambridge. I will be working on developing current light-sheet microscopes in the lab and then use them to perform 3D super-resolution imaging of proteins and other interest...
PhD STUDENTS
Kailai Xiong
Kelly is a PhD student working on using single-molecule methods to study the role of misfolded protein aggregates in neurodegenerative diseases, namely amylo...
Yuhao Cui
Yuhao is a PhD student working on single molecule studies of Toll-like receptor 4 signalling pathway. Prior to joining the Klenerman Lab in 2023, he obtained...
