Publications
Oligomer Diversity during the Aggregation of the Repeat Region of Tau.
2018
ACS Chemical Neuroscience
M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, D Klenerman
Mapping Surface Hydrophobicity of alpha-Synuclein Oligomers at the Nanoscale
2018
Nano Letters
J-E Lee, JC Sang, M Rodrigues, AR Carr, MH Horrocks, S De, MN Bongiovanni, P Flagmeier, CM Dobson, DJ Wales, SF Lee, D Klenerman
alpha-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease
2018
Nat Commun
MHR Ludtmann, PR Angelova, MH Horrocks, ML Choi, M Rodrigues, AY Baev, AV Berezhnov, Z Yao, D Little, B Banushi, AS Al-Menhali, RT Ranasinghe, DR Whiten, R Yapom, KS Dolt, MJ Devine, P Gissen, T Kunath, M Jaganjac, EV Pavlov, D Klenerman, AY Abramov, S Gandhi
Quantifying Co-Oligomer Formation by alpha-Synuclein
2018
ACS Nano
M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, TCT Michaels, D Frenkel, CM Dobson, TPJ Knowles, D Klenerman
Filamentous aggregates are fragmented by the proteasome holoenzyme
2018
Cell Reports
R Cliffe, J Sang, F Kundel, D Finley, D Klenerman, Y Ye
Sensitive light-sheet microscopy in multiwell plates using an AFM cantilever
2018
Biomedical Optics Express
A Ponjavic, Y Ye, E Laue, SF Lee, D Klenerman
Characterisation of particle-surface interactions via anharmonic acoustic transduction
2018
Sensors and Actuators B: Chemical
C da Silva Granja, N Sandström, I Efimov, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh
Correction to: Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
2018
Acta Neuropathologica
CD Hughes, ML Choi, M Ryten, L Hopkins, A Drews, JA Botía, M Iljina, M Rodrigues, SA Gagliano, S Gandhi, C Bryant, D Klenerman
Direct observation of murine prion protein replication in vitro
2018
Journal of the American Chemical Society
JC Sang, G Meisl, AM Thackray, L Hong, A Ponjavic, TPJ Knowles, R Bujdoso, D Klenerman
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells
2018
Chembiochem
DR Whiten, Y Zuo, L Calo, M-L Choi, S De, P Flagmeier, DC Wirthensohn, F Kundel, RT Ranasinghe, SE Sanchez, D Athauda, SF Lee, CM Dobson, S Gandhi, M-G Spillantini, D Klenerman, MH Horrocks
Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution.
2018
Anal Chem
CG Taylor, G Meisl, MH Horrocks, H Zetterberg, TPJ Knowles, D Klenerman
FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells
2018
Nature communications
S Basu, L-M Needham, D Lando, EJR Taylor, KJ Wohlfahrt, D Shah, W Boucher, YL Tan, LE Bates, O Tkachenko, J Cramard, BC Lagerholm, C Eggeling, B Hendrich, D Klenerman, SF Lee, ED Laue
Single molecule characterisation of the interactions between extracellular chaperones and toxic α-synuclein oligomers
2018
Cell Rep
DR Whiten, D Cox, MH Horrocks, CG Taylor, S De, P Flagmeier, L Tosatto, JR Kumita, H Ecroyd, CM Dobson, D Klenerman, MR Wilson
Alpha-synuclein induces ferroptosis through generation of lipid peroxidation and calcium deregulation
2018
Free Radical Biology and Medicine
PR Angelova, M-L Choi, MH Horrocks, D Klenerman, S Gandhi, AY Abramov
Single-Molecule Light-Sheet Imaging of Suspended T Cells
2018
Biophys J
A Ponjavic, J McColl, AR Carr, AM Santos, K Kulenkampff, A Lippert, SJ Davis, D Klenerman, SF Lee
Weighing one protein with light
2018
Science (New York, N.Y.)
SF Lee, D Klenerman
Combining fluorescence imaging with Hi-C to study 3D genome architecture of the same single cell.
2018
Nat Protoc
D Lando, S Basu, TJ Stevens, A Riddell, KJ Wohlfahrt, Y Cao, W Boucher, M Leeb, LP Atkinson, SF Lee, B Hendrich, D Klenerman, ED Laue
Anharmonic acoustic effects during DNA hybridization on an electrochemical quartz crystal resonator
2018
Electrochimica Acta
S Swarbrick, I Efimov, VP Ostanin, D Klenerman, A Stolzing, SK Ghosh
Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading
2018
ACS Chemical Neuroscience
F Kundel, L Hong, B Falcon, WA McEwan, TCT Michaels, G Meisl, N Esteras, AY Abramov, TJP Knowles, M Goedert, D Klenerman
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity.
2018
Journal of Biological Chemistry
D Cox, DR Whiten, JWP Brown, MH Horrocks, R San Gil, CM Dobson, D Klenerman, AM van Oijen, H Ecroyd
Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity
2018
ACS Chemical Biology
F Kundel, S De, P Flagmeier, MH Horrocks, M Kjaergaard, SL Shammas, SE Jackson, CM Dobson, D Klenerman
Capturing resting T cells: the perils of PLL.
2018
Nat Immunol
AM Santos, A Ponjavic, M Fritzsche, RA Fernandes, JB de la Serna, MJ Wilcock, F Schneider, I Urbančič, J McColl, C Anzilotti, KA Ganzinger, M Aßmann, D Depoil, RJ Cornall, ML Dustin, D Klenerman, SJ Davis, C Eggeling, SF Lee
Shedding light on aberrant interactions – a review of modern tools for studying protein aggregates
2018
The FEBS Journal
F Kundel, L Tosatto, DR Whiten, DC Wirthensohn, MH Horrocks, D Klenerman
Detecting RNA base methylations in single cells by in situ hybridization.
2018
Nat Commun
RT Ranasinghe, MR Challand, KA Ganzinger, BW Lewis, C Softley, WH Schmied, MH Horrocks, N Shivji, JW Chin, J Spencer, D Klenerman
Activation of toll-like receptors nucleates assembly of the MyDDosome signaling hub
2018
eLife
SL Latty, J Sakai, L Hopkins, B Verstak, T Paramo, NA Berglund, E Cammarota, P Cicuta, NJ Gay, PJ Bond, D Klenerman, CE Bryant
Optical structural analysis of individual α-synuclein oligomers
2018
Angewandte Chemie - International Edition
JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, D Klenerman, SF Lee
FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions
2018
Cell
S Qamar, G Wang, SJ Randle, FS Ruggeri, JA Varela, JQ Lin, EC Phillips, A Miyashita, D Williams, F Ströhl, W Meadows, R Ferry, VJ Dardov, GG Tartaglia, LA Farrer, GS Kaminski Schierle, CF Kaminski, CE Holt, PE Fraser, G Schmitt-Ulms, D Klenerman, T Knowles, M Vendruscolo, P St George-Hyslop
Single-Molecule Analysis of G Protein-Coupled Receptor Stoichiometry: Approaches and Limitations.
2018
Trends in Pharmacological Sciences
JH Felce, SJ Davis, D Klenerman
Monitoring Ca<sup>2+</sup> elevations in individual astrocytes upon local release of amyloid beta in acute brain slices
2018
Brain Research Bulletin
O Tyurikova, K Zheng, A Rings, A Drews, D Klenerman, DA Rusakov