Publications

Oligomer Diversity during the Aggregation of the Repeat Region of Tau.

2018

M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, D Klenerman

ACS Chemical Neuroscience

Mapping Surface Hydrophobicity of alpha-Synuclein Oligomers at the Nanoscale

2018

J-E Lee, JC Sang, M Rodrigues, AR Carr, MH Horrocks, S De, MN Bongiovanni, P Flagmeier, CM Dobson, DJ Wales, SF Lee, D Klenerman

Nano Letters

alpha-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease

2018

MHR Ludtmann, PR Angelova, MH Horrocks, ML Choi, M Rodrigues, AY Baev, AV Berezhnov, Z Yao, D Little, B Banushi, AS Al-Menhali, RT Ranasinghe, DR Whiten, R Yapom, KS Dolt, MJ Devine, P Gissen, T Kunath, M Jaganjac, EV Pavlov, D Klenerman, AY Abramov, S Gandhi

Nat Commun

Quantifying Co-Oligomer Formation by alpha-Synuclein

2018

M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, TCT Michaels, D Frenkel, CM Dobson, TPJ Knowles, D Klenerman

ACS Nano

Filamentous aggregates are fragmented by the proteasome holoenzyme

2018

R Cliffe, J Sang, F Kundel, D Finley, D Klenerman, Y Ye

Cell Reports

Sensitive light-sheet microscopy in multiwell plates using an AFM cantilever

2018

A Ponjavic, Y Ye, E Laue, SF Lee, D Klenerman

Biomedical Optics Express

Characterisation of particle-surface interactions via anharmonic acoustic transduction

2018

C da Silva Granja, N Sandström, I Efimov, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh

Sensors and Actuators B: Chemical

Correction to: Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis

2018

CD Hughes, ML Choi, M Ryten, L Hopkins, A Drews, JA Botía, M Iljina, M Rodrigues, SA Gagliano, S Gandhi, C Bryant, D Klenerman

Acta Neuropathologica

Direct observation of murine prion protein replication in vitro

2018

JC Sang, G Meisl, AM Thackray, L Hong, A Ponjavic, TPJ Knowles, R Bujdoso, D Klenerman

Journal of the American Chemical Society

Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells

2018

DR Whiten, Y Zuo, L Calo, M-L Choi, S De, P Flagmeier, DC Wirthensohn, F Kundel, RT Ranasinghe, SE Sanchez, D Athauda, SF Lee, CM Dobson, S Gandhi, M-G Spillantini, D Klenerman, MH Horrocks

Chembiochem

Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution.

2018

CG Taylor, G Meisl, MH Horrocks, H Zetterberg, TPJ Knowles, D Klenerman

Anal Chem

FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells

2018

S Basu, L-M Needham, D Lando, EJR Taylor, KJ Wohlfahrt, D Shah, W Boucher, YL Tan, LE Bates, O Tkachenko, J Cramard, BC Lagerholm, C Eggeling, B Hendrich, D Klenerman, SF Lee, ED Laue

Nature communications

Single molecule characterisation of the interactions between extracellular chaperones and toxic α-synuclein oligomers

2018

DR Whiten, D Cox, MH Horrocks, CG Taylor, S De, P Flagmeier, L Tosatto, JR Kumita, H Ecroyd, CM Dobson, D Klenerman, MR Wilson

Cell Rep

Alpha-synuclein induces ferroptosis through generation of lipid peroxidation and calcium deregulation

2018

PR Angelova, M-L Choi, MH Horrocks, D Klenerman, S Gandhi, AY Abramov

Free Radical Biology and Medicine

Single-Molecule Light-Sheet Imaging of Suspended T Cells

2018

A Ponjavic, J McColl, AR Carr, AM Santos, K Kulenkampff, A Lippert, SJ Davis, D Klenerman, SF Lee

Biophys J

Weighing one protein with light

2018

SF Lee, D Klenerman

Science (New York, N.Y.)

Phase Separation of FUS is Modulated by Methylation State of Cation-π Interactions and Interaction with TNPO1

2018

PH St George-Hyslop, S Qamar, G Wang, SJ Randle, FS Ruggeri, J Varela, CF Kaminski, GS Kaminski, M Vendruscolo, TPJ Knowles, D Klenerman, CE Holt, Q Lin, W meadows

Cell

Combining fluorescence imaging with Hi-C to study 3D genome architecture of the same single cell.

2018

D Lando, S Basu, TJ Stevens, A Riddell, KJ Wohlfahrt, Y Cao, W Boucher, M Leeb, LP Atkinson, SF Lee, B Hendrich, D Klenerman, ED Laue

Nat Protoc

Anharmonic acoustic effects during DNA hybridization on an electrochemical quartz crystal resonator

2018

S Swarbrick, I Efimov, VP Ostanin, D Klenerman, A Stolzing, SK Ghosh

Electrochimica Acta

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading

2018

F Kundel, L Hong, B Falcon, WA McEwan, TCT Michaels, G Meisl, N Esteras, AY Abramov, TJP Knowles, M Goedert, D Klenerman

ACS Chemical Neuroscience

The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity.

2018

D Cox, DR Whiten, JWP Brown, MH Horrocks, R San Gil, CM Dobson, D Klenerman, AM van Oijen, H Ecroyd

Journal of Biological Chemistry

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

2018

F Kundel, S De, P Flagmeier, MH Horrocks, M Kjaergaard, SL Shammas, SE Jackson, CM Dobson, D Klenerman

ACS Chemical Biology

Capturing resting T cells: the perils of PLL.

2018

AM Santos, A Ponjavic, M Fritzsche, RA Fernandes, JB de la Serna, MJ Wilcock, F Schneider, I Urbančič, J McColl, C Anzilotti, KA Ganzinger, M Aßmann, D Depoil, RJ Cornall, ML Dustin, D Klenerman, SJ Davis, C Eggeling, SF Lee

Nat Immunol

Shedding light on aberrant interactions – a review of modern tools for studying protein aggregates

2018

F Kundel, L Tosatto, DR Whiten, DC Wirthensohn, MH Horrocks, D Klenerman

The FEBS Journal

Detecting RNA base methylations in single cells by in situ hybridization.

2018

RT Ranasinghe, MR Challand, KA Ganzinger, BW Lewis, C Softley, WH Schmied, MH Horrocks, N Shivji, JW Chin, J Spencer, D Klenerman

Nat Commun

Activation of toll-like receptors nucleates assembly of the MyDDosome signaling hub

2018

SL Latty, J Sakai, L Hopkins, B Verstak, T Paramo, NA Berglund, E Cammarota, P Cicuta, NJ Gay, PJ Bond, D Klenerman, CE Bryant

eLife

Optical structural analysis of individual α-synuclein oligomers

2018

JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, D Klenerman, SF Lee

Angewandte Chemie - International Edition

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

2018

S Qamar, G Wang, SJ Randle, FS Ruggeri, JA Varela, JQ Lin, EC Phillips, A Miyashita, D Williams, F Ströhl, W Meadows, R Ferry, VJ Dardov, GG Tartaglia, LA Farrer, GS Kaminski Schierle, CF Kaminski, CE Holt, PE Fraser, G Schmitt-Ulms, D Klenerman, T Knowles, M Vendruscolo, P St George-Hyslop

Cell

Single-Molecule Analysis of G Protein-Coupled Receptor Stoichiometry: Approaches and Limitations.

2018

JH Felce, SJ Davis, D Klenerman

Trends in Pharmacological Sciences

Monitoring Ca<sup>2+</sup> elevations in individual astrocytes upon local release of amyloid beta in acute brain slices

2018

O Tyurikova, K Zheng, A Rings, A Drews, D Klenerman, DA Rusakov

Brain Research Bulletin

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