Publications

pyFRET: A Python Library for Single Molecule Fluorescence Data Analysis

2016

RR Murphy, SE Jackson, D Klenerman

Proceedings of the 7th European Conference on Python in Science (EuroSciPy 2014)

Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping

2016

MN Bongiovanni, J Godet, MH Horrocks, L Tosatto, AR Carr, DC Wirthensohn, RT Ranasinghe, J-E Lee, A Ponjavic, JV Fritz, CM Dobson, D Klenerman, SF Lee

Nature communications

Low Stress Ion Conductance Microscopy of Sub-Cellular Stiffness

2016

RW Clarke, P Novak, A Zhukov, EJ Tyler, M Cano-Jaimez, A Drews, O Richards, K Volynski, C Bishop, D Klenerman

Soft matter

Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein

2016

M Iljina, L Tosatto, ML Choi, JC Sang, Y Ye, CD Hughes, CE Bryant, S Gandhi, D Klenerman

Sci Rep

A microfluidic platform for trapping, releasing and super-resolution imaging of single cells

2016

Y Zhou, S Basu, KJ Wohlfahrt, SF Lee, D Klenerman, ED Laue, AA Seshia

Sensors and actuators. B, Chemical

Individual aggregates of amyloid beta induce temporary calcium influx through the cell membrane of neuronal cells

2016

A Drews, J Flint, N Shivji, P Jönsson, D Wirthensohn, E De Genst, C Vincke, S Muyldermans, C Dobson, D Klenerman

Sci Rep

The Nucleosome Remodeling and Deacetylase Complex NuRD Is Built from Preformed Catalytically Active Sub-modules.

2016

W Zhang, A Aubert, JM Gomez de Segura, M Karuppasamy, S Basu, AS Murthy, A Diamante, TA Drury, J Balmer, J Cramard, AA Watson, D Lando, SF Lee, M Palayret, SL Kloet, AH Smits, MJ Deery, M Vermeulen, B Hendrich, D Klenerman, C Schaffitzel, I Berger, ED Laue

J Mol Biol

A novel single molecule imaging approach to detect individual protein oligomers in CSF from patients with Parkinson's disease (PD)

2016

S Gandhi, MH Horrocks, SF Lee, NW Wood, D Klenerman

MOVEMENT DISORDERS

Angular Approach Scanning Ion Conductance Microscopy

2016

A Shevchuk, S Tokar, S Gopal, JL Sanchez-Alonso, AI Tarasov, AC Vélez-Ortega, C Chiappini, P Rorsman, MM Stevens, J Gorelik, GI Frolenkov, D Klenerman, YE Korchev

Biophysical journal

Ca2+is a key factor in α-synuclein-induced neurotoxicity

2016

PR Angelova, MHR Ludtmann, MH Horrocks, A Negoda, N Cremades, D Klenerman, CM Dobson, NW Wood, EV Pavlov, S Gandhi, AY Abramov

Development

Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions.

2016

P Jönsson, JH Southcombe, AM Santos, J Huo, RA Fernandes, J McColl, M Lever, EJ Evans, A Hudson, VT Chang, T Hanke, A Godkin, PD Dunne, MH Horrocks, M Palayret, GR Screaton, J Petersen, J Rossjohn, L Fugger, O Dushek, X-N Xu, SJ Davis, D Klenerman

Proc Natl Acad Sci U S A

Initiation of T cell signaling by CD45 segregation at 'close contacts'.

2016

VT Chang, RA Fernandes, KA Ganzinger, SF Lee, C Siebold, J McColl, P Jönsson, M Palayret, K Harlos, CH Coles, EY Jones, Y Lui, E Huang, RJC Gilbert, D Klenerman, AR Aricescu, SJ Davis

Nat Immunol

Ca2+is a key factor in α-synuclein-induced neurotoxicity

2016

PR Angelova, MHR Ludtmann, MH Horrocks, A Negoda, N Cremades, D Klenerman, CM Dobson, NW Wood, EV Pavlov, S Gandhi, AY Abramov

J Cell Sci

Combining Single-Molecule Techniques with Microfluidics for Protein Analysis

2016

C Taylor, T Knowles, D Klenerman

Biophysical Journal

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.

2016

M Iljina, GA Garcia, MH Horrocks, L Tosatto, ML Choi, KA Ganzinger, AY Abramov, S Gandhi, NW Wood, N Cremades, CM Dobson, TPJ Knowles, D Klenerman

Proceedings of the National Academy of Sciences of the United States of America

Spearhead Nanometric Field-Effect Transistor Sensors for Single-Cell Analysis

2016

Y Zhang, J Clausmeyer, B Babakinejad, AL Córdoba, T Ali, A Shevchuk, Y Takahashi, P Novak, C Edwards, M Lab, S Gopal, C Chiappini, U Anand, L Magnani, RC Coombes, J Gorelik, T Matsue, W Schuhmann, D Klenerman, EV Sviderskaya, Y Korchev

ACS Nano

Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids

2016

MH Horrocks, SF Lee, S Gandhi, NK Magdalinou, SW Chen, MJ Devine, L Tosatto, M Kjaergaard, JS Beckwith, H Zetterberg, M Iljina, N Cremades, CM Dobson, NW Wood, D Klenerman

ACS chemical neuroscience

PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits.

2016

MJ Broadhead, MH Horrocks, F Zhu, L Muresan, R Benavides-Piccione, J DeFelipe, D Fricker, MV Kopanitsa, RR Duncan, D Klenerman, NH Komiyama, SF Lee, SGN Grant

Sci Rep

Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms

2016

M Iljina, GA Garcia, AJ Dear, J Flint, P Narayan, TCT Michaels, CM Dobson, D Frenkel, TPJ Knowles, D Klenerman

Sci Rep

A single-molecule approach to deciphering the mechanism of T-cell receptor triggering.

2016

KA Ganzinger, R Fernandes, S Lee, M Palayret, P Jonsson, J McColl, SJ Davis, D Klenerman

MOLECULAR BIOLOGY OF THE CELL

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease.

2016

E Deas, N Cremades, PR Angelova, MHR Ludtmann, Z Yao, S Chen, MH Horrocks, B Banushi, D Little, MJ Devine, P Gissen, D Klenerman, CM Dobson, NW Wood, S Gandhi, AY Abramov

Antioxid Redox Signal

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