Publications
Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies.
2020
Sanderson JB, De S, Jiang H, Rovere M, Jin M, Zaccagnini L, Hays Watson A, De Boni L, Lagomarsino VN, Young-Pearse TL, Liu X, Pochapsky TC, Hyman BT, Dickson DW, Klenerman D, Selkoe DJ, Bartels T.
Brain Commun.
Digital Sensing and Molecular Computation by an Enzyme-Free DNA Circuit.
2020
Arter WE, Yusim Y, Peter Q, Taylor CG, Klenerman D, Keyser UF, Knowles TPJ
ACS Nano.
The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.
2020
Meisl G, Knowles TP, Klenerman D.
Curr Opin Neurobiol.
The Costs of Close Contacts: Visualizing the Energy Landscape of Cell Contacts at the Nanoscale.
2020
Kulenkampff K, Lippert AH, McColl J, Santos AM, Ponjavic A, Jenkins E, Humphrey J, Winkel A, Franze K, Lee SF, Davis SJ, Klenerman D.
Biophys J.
Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death.
2020
Hughes C, Choi ML, Yi JH, Kim SC, Drews A, George-Hyslop PS, Bryant C, Gandhi S, Cho K, Klenerman D.
Commun Biol.
MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling.
2020
Moncrieffe MC, Bollschweiler D, Li B, Penczek PA, Hopkins L, Bryant CE, Klenerman D, Gay NJ.
Structure
A General in Vitro Assay for Studying Enzymatic Activities of the Ubiquitin System.
2020
Zuo Y, Chong BK, Jiang K, Finley D, Klenerman D, Ye Y.
Biochemistry
α-Synuclein strains target distinct brain regions and cell types.
2020
Lau A, So RWL, Lau HHC, Sang JC, Ruiz-Riquelme A, Fleck SC, Stuart E, Menon S, Visanji NP, Meisl G, Faidi R, Marano MM, Schmitt-Ulms C, Wang Z, Fraser PE, Tandon A, Hyman BT, Wille H, Ingelsson M, Klenerman D, Watts JC.
Nat Neurosci.
N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme
2020
Ye Y, Klenerman D, Finley D.
J Mol Biol.
Nanoscale-targeted patch-clamp recordings of functional presynaptic ion channels.
2013
P Novak, J Gorelik, U Vivekananda, AI Shevchuk, YS Ermolyuk, RJ Bailey, AJ Bushby, GWJ Moss, DA Rusakov, D Klenerman, DM Kullmann, KE Volynski, YE Korchev
Neuron
Local delivery of molecules from a nanopipette for quantitative receptor mapping on live cells
2013
B Babakinejad, P Jönsson, A López Córdoba, P Actis, P Novak, Y Takahashi, A Shevchuk, U Anand, P Anand, A Drews, A Ferrer-Montiel, D Klenerman, YE Korchev
Analytical Chemistry
A Single gD Glycoprotein Can Mediate Infection by Herpes simplex Virus
2013
RW Clarke, A Drews, H Browne, D Klenerman
Journal of the American Chemical Society
Ultrarapid Generation of Femtoliter Microfluidic Droplets for Single-Molecule-Counting Immunoassays
2013
J-U Shim, RT Ranasinghe, CA Smith, SM Ibrahim, F Hollfelder, WTS Huck, D Klenerman, C Abell
ACS Nano
Single-molecule measurements of transient biomolecular complexes through microfluidic dilution
2013
MH Horrocks, L Rajah, P Jönsson, M Kjaergaard, M Vendruscolo, TPJ Knowles, D Klenerman
Analytical chemistry
Highly Rapid Amplification-Free and Quantitative DNA Imaging Assay
2013
T Klamp, M Camps, B Nieto, F Guasch, RT Ranasinghe, J Wiedemann, Z Petrášek, P Schwille, D Klenerman, M Sauer
Scientific reports
Three-Dimensional RNA Structure of the Major HIV-1 Packaging Signal Region
2013
JD Stephenson, H Li, JC Kenyon, M Symmons, D Klenerman, AML Lever
Structure
Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells
2013
P Narayan, KA Ganzinger, J McColl, L Weimann, S Meehan, S Qamar, JA Carver, MR Wilson, P St George-Hyslop, CM Dobson, D Klenerman
J Am Chem Soc
Imaging the cell surface and its organization down to the level of single molecules.
2013
D Klenerman, A Shevchuk, P Novak, YE Korchev, SJ Davis
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
A quantitative comparison of single-dye tracking analysis tools using Monte Carlo simulations.
2013
L Weimann, KA Ganzinger, J McColl, KL Irvine, SJ Davis, NJ Gay, CE Bryant, D Klenerman
PloS one
Imaging the cell surface and its organization down to the level of single molecules
2013
D Klenerman, A Shevchuk, P Novak, YE Korchev, SJ Davis
Philosophical Transactions of the Royal Society B: Biological Sciences
Three-dimensional RNA structure of the major HIV-1 packaging signal region
2013
JD Stephenson, H Li, JC Kenyon, M Symmons, D Klenerman, AML Lever
Structure
Ubiquitin chain conformation regulates recognition and activity of interacting proteins
2012
Y Ye, G Blaser, MH Horrocks, MJ Ruedas-Rama, S Ibrahim, AA Zhukov, A Orte, D Klenerman, SE Jackson, D Komander
Nature
Pipette–Surface Interaction: Current Enhancement and Intrinsic Force
2013
RW Clarke, A Zhukov, O Richards, N Johnson, V Ostanin, D Klenerman
J Am Chem Soc
Amyloid-β Oligomers are Sequestered by both Intracellular and Extracellular Chaperones
2012
P Narayan, S Meehan, JA Carver, MR Wilson, CM Dobson, D Klenerman
Biochemistry
A hybrid scanning mode for fast scanning ion conductance microscopy (SICM) imaging.
2012
A Zhukov, O Richards, V Ostanin, Y Korchev, D Klenerman
Ultramicroscopy
Quantitative single-molecule microscopy reveals that CENP-A(Cnp1) deposition occurs during G2 in fission yeast
2012
D Lando, U Endesfelder, H Berger, L Subramanian, PD Dunne, J McColl, D Klenerman, AM Carr, M Sauer, RC Allshire, M Heilemann, ED Laue
Open biology
Hydrodynamic trapping of molecules in lipid bilayers
2012
P Jönsson, J McColl, RW Clarke, VP Ostanin, B Jönsson, D Klenerman
Proceedings of the National Academy of Sciences of the United States of America
Direct observation of the interconversion of normal and toxic forms of α-synuclein.
2012
N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, M Sandal, RW Clarke, P Dunne, FA Aprile, CW Bertoncini, NW Wood, TPJ Knowles, CM Dobson, D Klenerman
Cell
Topographical and electrochemical nanoscale imaging of living cells using voltage-switching mode scanning electrochemical microscopy
2012
Y Takahashi, AI Shevchuk, P Novak, B Babakinejad, J Macpherson, PR Unwin, H Shiku, J Gorelik, D Klenerman, YE Korchev, T Matsue
Proceedings of the National Academy of Sciences
An alternative mechanism of clathrin-coated pit closure revealed by ion conductance microscopy.
2012
AI Shevchuk, P Novak, M Taylor, IA Diakonov, A Ziyadeh-Isleem, M Bitoun, P Guicheney, MJ Lab, J Gorelik, CJ Merrifield, D Klenerman, YE Korchev
The Journal of Cell Biology
The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β 1-40 peptide
2012
P Narayan, A Orte, RW Clarke, B Bolognesi, S Hook, KA Ganzinger, S Meehan, MR Wilson, CM Dobson, D Klenerman
Nature Structural and Molecular Biology
Ubiquitin chain conformation regulates recognition and activity of interacting proteins
2012
Y Ye, G Blaser, MH Horrocks, MJ Ruedas-Rama, S Ibrahim, AA Zhukov, A Orte, D Klenerman, SE Jackson, D Komander
Nature
Single Molecule Fluorescence under Conditions of Fast Flow
2012
MH Horrocks, H Li, J-U Shim, RT Ranasinghe, RW Clarke, WTS Huck, C Abell, D Klenerman
Analytical Chemistry
Separation and detection of bacteria using rupture event scanning
2011
MA Cooper, FN Dultsev, VP Ostanin, D Klenerman
Analytica Chimica Acta
Multifunctional Nanoprobes for Nanoscale Chemical Imaging and Localized Chemical Delivery at Surfaces and Interfaces
2011
Y Takahashi, AI Shevchuk, P Novak, Y Zhang, N Ebejer, JV Macpherson, PR Unwin, AJ Pollard, D Roy, CA Clifford, H Shiku, T Matsue, D Klenerman, YE Korchev
Angew Chem Int Ed Engl
The T cell receptor triggering apparatus is composed of monovalent or monomeric proteins
2011
JR James, J McColl, MI Oliveira, PD Dunne, E Huang, A Jansson, P Nilsson, DL Sleep, CM Gonçalves, SH Morgan, JH Felce, R Mahen, RA Fernandes, AM Carmo, D Klenerman, SJ Davis
The Journal of biological chemistry
Imaging and characterisation of the surface of live cells
2011
D Klenerman, YE Korchev, SJ Davis
Current Opinion in Chemical Biology
Realizing the biological and biomedical potential of nanoscale imaging using a pipette probe
2011
AI Shevchuk, P Novak, Y Takahashi, R Clarke, M Miragoli, B Babakinejad, J Gorelik, YE Korchev, D Klenerman
Nanomedicine (London, England)
Scanning ion conductance microscopy: a convergent high-resolution technology for multi-parametric analysis of living cardiovascular cells
2011
M Miragoli, A Moshkov, P Novak, A Shevchuk, VO Nikolaev, I El-Hamamsy, CMF Potter, P Wright, SHSA Kadir, AR Lyon, JA Mitchell, AH Chester, D Klenerman, MJ Lab, YE Korchev, SE Harding, J Gorelik
Journal of the Royal Society Interface
Multifunctional nanoprobes for nanoscale chemical imaging and localized chemical delivery at surfaces and interfaces
2011
Y Takahashi, AI Shevchuk, P Novak, Y Zhang, N Ebejer, JV MacPherson, PR Unwin, AJ Pollard, D Roy, CA Clifford, H Shiku, T Matsue, D Klenerman, YE Korchev
Angewandte Chemie - International Edition
Imaging and characterisation of the surface of live cells
2011
D Klenerman, YE Korchev, SJ Davis
Current Opinion in Chemical Biology
A chelating dendritic ligand capped quantum dot: preparation, surface passivation, bioconjugation and specific DNA detection.
2011
D Zhou, Y Li, EAH Hall, C Abell, D Klenerman
Nanoscale
Single-molecule fluorescence coincidence spectroscopy and its application to resonance energy transfer
2011
A Orte, RW Clarke, D Klenerman
ChemPhysChem
Single-molecule two-colour coincidence detection to probe biomolecular associations.
2010
A Orte, R Clarke, D Klenerman
Biochem Soc Trans
Selective Diffusion Barriers Separate Membrane Compartments
2010
A Bruckbauer, PD Dunne, P James, E Howes, D Zhou, R Jones, D Klenerman
Biophys J
Tracking diffusion of GM1 gangliosides and zona pellucida binding molecules in sperm plasma membranes following cholesterol efflux
2010
R Jones, E Howes, PD Dunne, P James, A Bruckbauer, D Klenerman
Dev Biol
RNA Conformation in Catalytically Active Human Telomerase
2010
JA Yeoman, A Orte, B Ashbridge, D Klenerman, S Balasubramanian
Journal of the American Chemical Society
Taking T cells beyond the diffraction limit.
2010
PA van der Merwe, PD Dunne, D Klenerman, SJ Davis
Nature immunology
Selective diffusion barriers separate membrane compartments
2010
A Bruckbauer, PD Dunne, P James, E Howes, D Zhou, R Jones, D Klenerman
Biophysical Journal
Nanoscale live-cell imaging using hopping probe ion conductance microscopy
2009
P Novak, C Li, AI Shevchuk, R Stepanyan, M Caldwell, S Hughes, TG Smart, J Gorelik, VP Ostanin, MJ Lab, GWJ Moss, GI Frolenkov, D Klenerman, YE Korchev
NATURE METHODS
Single-Molecule Analysis of the Human Telomerase RNA center dot Dyskerin Interaction and the Effect of Dyskeratosis Congenita Mutations
2009
B Ashbridge, A Orte, JA Yeoman, M Kirwan, T Vulliamy, I Dokal, D Klenerman, S Balasubramanian
Biochemistry
Probing neuroserpin polymerization and interaction with amyloid-beta peptides using single molecule fluorescence.
2009
A Chiou, P Hägglöf, A Orte, AY Chen, PD Dunne, D Belorgey, S Karlsson-Li, DA Lomas, D Klenerman
Biophysical Journal
DySCo: quantitating associations of membrane proteins using two-color single-molecule tracking.
2009
PD Dunne, RA Fernandes, J McColl, JW Yoon, JR James, SJ Davis, D Klenerman
Biophysical Journal
The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange
2009
MKK Shivji, SR Mukund, E Rajendra, S Chen, JM Short, J Savill, D Klenerman, AR Venkitaraman
Proceedings of the National Academy of Sciences
Nanoscale live-cell imaging using hopping probe ion conductance microscopy.
2009
P Novak, C Li, AI Shevchuk, R Stepanyan, M Caldwell, S Hughes, TG Smart, J Gorelik, VP Ostanin, MJ Lab, GWJ Moss, GI Frolenkov, D Klenerman, YE Korchev
Nat Methods
Non-invasive imaging of stem cells by scanning ion conductance microscopy: future perspective.
2008
J Gorelik, NN Ali, SH Sheikh Abdul Kadir, M Lab, P Stojkovic, L Armstrong, EV Sviderskaya, YA Negulyaev, D Klenerman, DC Bennett, M Lako, SE Harding, M Stojkovic, YE Korchev
Tissue Eng Part C Methods
Fluorescence Coincidence Spectroscopy for Single-Molecule Fluorescence Resonance Energy-Transfer Measurements
2008
A Orte, RW Clarke, D Klenerman
Analytical Chemistry
Accurate whole human genome sequencing using reversible terminator chemistry
2008
DR Bentley, S Balasubramanian, HP Swerdlow, GP Smith, J Milton, CG Brown, KP Hall, DJ Evers, CL Barnes, HR Bignell, JM Boutell, J Bryant, RJ Carter, R Keira Cheetham, AJ Cox, DJ Ellis, MR Flatbush, NA Gormley, SJ Humphray, LJ Irving, MS Karbelashvili, SM Kirk, H Li, X Liu, KS Maisinger, LJ Murray, B Obradovic, T Ost, ML Parkinson, MR Pratt, IMJ Rasolonjatovo, MT Reed, R Rigatti, C Rodighiero, MT Ross, A Sabot, SV Sankar, A Scally, GP Schroth, ME Smith, VP Smith, A Spiridou, PE Torrance, SS Tzonev, EH Vermaas, K Walter, X Wu, L Zhang, MD Alam, C Anastasi, IC Aniebo, DMD Bailey, IR Bancarz, S Banerjee, SG Barbour, PA Baybayan, VA Benoit, KF Benson, C Bevis, PJ Black, A Boodhun, JS Brennan, JA Bridgham, RC Brown, AA Brown, DH Buermann, AA Bundu, JC Burrows, NP Carter, N Castillo, M Chiara E Catenazzi, S Chang, R Neil Cooley, NR Crake, OO Dada, KD Diakoumakos, B Dominguez-Fernandez, DJ Earnshaw, UC Egbujor, DW Elmore, SS Etchin, MR Ewan, M Fedurco, LJ Fraser, KV Fuentes Fajardo, W Scott Furey, D George, KJ Gietzen, CP Goddard, GS Golda, PA Granieri, DE Green, DL Gustafson, NF Hansen, K Harnish, CD Haudenschild, NI Heyer, MM Hims, JT Ho, AM Horgan, K Hoschler, S Hurwitz, DV Ivanov, MQ Johnson, T James, TA Huw Jones, G-D Kang, TH Kerelska, AD Kersey, I Khrebtukova, AP Kindwall, Z Kingsbury, PI Kokko-Gonzales, A Kumar, MA Laurent, CT Lawley, SE Lee, X Lee, AK Liao, JA Loch, M Lok, S Luo, RM Mammen, JW Martin, PG McCauley, P McNitt, P Mehta, KW Moon, JW Mullens, T Newington, Z Ning, B Ling Ng, SM Novo, MJ O'Neill, MA Osborne, A Osnowski, O Ostadan, LL Paraschos, L Pickering, AC Pike, AC Pike, D Chris Pinkard, DP Pliskin, J Podhasky, VJ Quijano, C Raczy, VH Rae, SR Rawlings, A Chiva Rodriguez, PM Roe, J Rogers, MC Rogert Bacigalupo, N Romanov, A Romieu, RK Roth, NJ Rourke, ST Ruediger, E Rusman, RM Sanches-Kuiper, MR Schenker, JM Seoane, RJ Shaw, MK Shiver, SW Short, NL Sizto, JP Sluis, MA Smith, J Ernest Sohna Sohna, EJ Spence, K Stevens, N Sutton, L Szajkowski, CL Tregidgo, G Turcatti, S Vandevondele, Y Verhovsky, SM Virk, S Wakelin, GC Walcott, J Wang, GJ Worsley, J Yan, L Yau, M Zuerlein, J Rogers, JC Mullikin, ME Hurles, NJ McCooke, JS West, FL Oaks, PL Lundberg, D Klenerman, R Durbin, AJ Smith
Nature
Direct characterization of amyloidogenic oligomers by single-molecule fluorescence
2008
A Orte, NR Birkett, RW Clarke, GL Devlin, CM Dobson, D Klenerman
Proceedings of the National Academy of Sciences of the United States of America
Noncontact measurement of the local mechanical properties of living cells using pressure applied via a pipette
2008
D Sánchez, N Johnson, C Li, P Novak, J Rheinlaender, Y Zhang, U Anand, P Anand, J Gorelik, GI Frolenkov, C Benham, M Lab, VP Ostanin, TE Schäffer, D Klenerman, YE Korchev
Biophysical journal
Characterization and application of controllable local chemical changes produced by reagent delivery from a nanopipet.
2008
JD Piper, C Li, C-J Lo, R Berry, Y Korchev, L Ying, D Klenerman
J Am Chem Soc
High resolution imaging using scanning ion conductance microscopy with improved distance feedback control
2008
C Li, N Johnson, V Ostanin, A Shevchuk, LM Ying, Y Korchev, D Klenerman
Progress in Natural Science
Bayesian inference for improved single molecule fluorescence tracking
2008
JW Yoon, A Bruckbauer, WJ Fitzgerald, D Klenerman
Biophys J
Imaging single virus particles on the surface of cell membranes by high-resolution scanning surface confocal microscopy.
2008
AI Shevchuk, P Hobson, MJ Lab, D Klenerman, N Krauzewicz, YE Korchev
Biophysical journal
Single-molecule analysis of human telomerase monomer.
2008
D Alves, H Li, R Codrington, A Orte, X Ren, D Klenerman, S Balasubramanian
Nature chemical biology
Endocytic pathways: combined scanning ion conductance and surface confocal microscopy study
2008
AI Shevchuk, P Hobson, MJ Lab, D Klenerman, N Krauzewicz, YE Korchev
Pflugers Arch
A Compact Functional Quantum Dot−DNA Conjugate: Preparation, Hybridization, and Specific Label-Free DNA Detection
2008
D Zhou, L Ying, X Hong, EA Hall, C Abell, D Klenerman
Langmuir : the ACS journal of surfaces and colloids
Noncontact measurement of the local mechanical properties of living cells using pressure applied via a pipette
2008
D Sánchez, N Johnson, C Li, P Novak, J Rheinlaender, Y Zhang, U Anand, P Anand, J Gorelik, GI Frolenkov, C Benham, M Lab, VP Ostanin, TE Schäffer, D Klenerman, YE Korchev
Biophysical Journal
Evidence of an Intermediate and Parallel Pathways in Protein Unfolding from Single-Molecule Fluorescence
2008
A Orte, TD Craggs, SS White, SE Jackson, D Klenerman
Journal of the American Chemical Society
Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells
2007
JR James, SS White, RW Clarke, AM Johansen, PD Dunne, DL Sleep, WJ Fitzgerald, SJ Davis, D Klenerman
Proceedings of the National Academy of Sciences
Nanopipette delivery of individual molecules to cellular compartments for single-molecule fluorescence tracking.
2007
A Bruckbauer, P James, D Zhou, JW Yoon, D Excell, Y Korchev, R Jones, D Klenerman
Biophysical journal
Two-color fluorescence analysis of individual virions determines the distribution of the copy number of proteins in herpes simplex virus particles.
2007
RW Clarke, N Monnier, H Li, D Zhou, H Browne, D Klenerman
Biophysical Journal
Supramolecular organization of the sperm plasma membrane during maturation and capacitation
2007
R Jones, PS James, L Howes, A Bruckbauer, D Klenerman
Asian J Androl
Basolateral P2X4-like receptors regulate the extracellular ATP-stimulated epithelial Na+ channel activity in renal epithelia.
2007
Y Zhang, D Sanchez, J Gorelik, D Klenerman, M Lab, C Edwards, Y Korchev
Am J Physiol Renal Physiol
Surface Conductivity of Biological Macromolecules Measured by Nanopipette Dielectrophoresis
2007
RW Clarke, JD Piper, L Ying, D Klenerman
Phys Rev Lett
Optimized threshold selection for single-molecule two-color fluorescence coincidence spectroscopy.
2007
RW Clarke, A Orte, D Klenerman
Anal Chem
Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy.
2007
D Sánchez, U Anand, J Gorelik, CD Benham, C Bountra, M Lab, D Klenerman, R Birch, P Anand, Y Korchev
Journal of Neuroscience Methods
Basolateral P2X<inf>4</inf>-like receptors regulate the extracellular ATP-stimulated epithelial Na<sup>+</sup> channel activity in renal epithelia
2007
Y Zhang, D Sanchez, J Gorelik, D Klenerman, M Lab, C Edwards, Y Korchev
American Journal of Physiology - Renal Physiology
A Renewable Nanosensor Based on a Glass Nanopipette
2006
JD Piper, RW Clarke, YE Korchev, L Ying, D Klenerman
J Am Chem Soc
A Simple Nanomixer for Single-Molecule Kinetics Measurements
2006
SS White, S Balasubramanian, D Klenerman, L Ying
Angewandte Chemie
Determination of the Fraction and Stoichiometry of Femtomolar Levels of Biomolecular Complexes in an Excess of Monomer Using Single-Molecule, Two-Color Coincidence Detection
2006
A Orte, R Clarke, S Balasubramanian, D Klenerman
Analytical chemistry
Structural analysis of the catalytic core of human telomerase RNA by FRET and molecular modeling
2006
G Gavory, MF Symmons, Y Krishnan Ghosh, D Klenerman, S Balasubramanian
Biochemistry
Characterization of a single molecule DNA switch in free solution.
2006
SS White, H Li, RJ Marsh, JD Piper, ND Leonczek, N Nicolaou, AJ Bain, L Ying, D Klenerman
J Am Chem Soc
Investigating a Quadruplex−Ligand Interaction by Unfolding Kinetics
2006
JJ Green, S Ladame, L Ying, D Klenerman, S Balasubramanian
J Am Chem Soc
Potential biomedical applications of the scanned nanopipette.
2006
D Klenerman, Y Korchev
Nanomedicine (Lond)
Evidence for resonance optical trapping of individual fluorophore-labeled antibodies using single molecule fluorescence spectroscopy.
2006
H Li, D Zhou, H Browne, D Klenerman
Journal of the American Chemical Society
Building three-dimensional nanostructures with active enzymes by surface templated layer-by-layer assembly.
2006
S Rauf, D Zhou, C Abell, D Klenerman, D-J Kang
Chemical communications (Cambridge, England)
Analysis of human telomerase activity and function by two color single molecule coincidence fluorescence spectroscopy.
2006
X Ren, H Li, RW Clarke, DA Alves, L Ying, D Klenerman, S Balasubramanian
Journal of the American Chemical Society
Imaging Proteins in Membranes of Living Cells by High-Resolution Scanning Ion Conductance Microscopy
2006
AI Shevchuk, GI Frolenkov, D Sánchez, PS James, N Freedman, MJ Lab, R Jones, D Klenerman, YE Korchev
Angewandte Chemie (International ed. in English)
Macroscopic 2D networks self-assembled from nanometer-sized protein/DNA complexes.
2006
M Manzanera, DJ Frankel, H Li, D Zhou, A Bruckbauer, P Kreutzmann, JM Blackburn, C Abell, T Rayment, D Klenerman, PD Barker
Nano letters
A reversible pH-driven DNA nanoswitch array.
2006
D Liu, A Bruckbauer, C Abell, S Balasubramanian, D-J Kang, D Klenerman, D Zhou
Journal of the American Chemical Society
Nanoscale pipetting for controlled chemistry in small arrayed water droplets using a double-barrel pipet
2006
KT Rodolfa, A Bruckbauer, D Zhou, AI Schevchuk, YE Korchev, D Klenerman
Nano Letters
A simple nanomixer for single-molecule kinetics measurements.
2006
SS White, S Balasubramanian, D Klenerman, L Ying
Angewandte Chemie - International Edition
Two-component graded deposition of biomolecules with a double-barreled nanopipette.
2005
KT Rodolfa, A Bruckbauer, D Zhou, YE Korchev, D Klenerman
Angew Chem Int Ed Engl
Two-Component Graded Deposition of Biomolecules with a Double-Barreled Nanopipette
2005
KT Rodolfa, A Bruckbauer, D Zhou, YE Korchev, D Klenerman
Angewandte Chemie
Aldosterone acts via an ATP autocrine/paracrine system: the Edelman ATP hypothesis revisited.
2005
J Gorelik, Y Zhang, D Sánchez, A Shevchuk, G Frolenkov, M Lab, D Klenerman, C Edwards, Y Korchev
Proceedings of the National Academy of Sciences of the United States of America
Fluorescence resonance energy transfer between a quantum dot donor and a dye acceptor attached to DNA
2005
D Zhou, JD Piper, C Abell, D Klenerman, D-J Kang, L Ying
Chem Commun (Camb)
Scanning ion conductance microscopy reveals how a functional renal epithelial monolayer maintains its integrity
2005
Y Zhang, J Gorelik, D Sanchez, A Shevchuk, M Lab, I Vodyanoy, D Klenerman, C Edwards, Y Korchev
Kidney Int
The scanned nanopipette: A new tool for high resolution bioimaging and controlled deposition of biomolecules
2005
L Ying, A Bruckbauer, D Zhou, J Gorelik, A Shevchuk, M Lab, Y Korchev, D Klenerman
Physical Chemistry Chemical Physics
Trapping of Proteins under Physiological Conditions in a Nanopipette
2005
RW Clarke, SS White, D Zhou, L Ying, D Klenerman
Angew Chem Int Ed Engl
Fabrication of three-dimensional surface structures with highly fluorescent quantum dots by surface-templated layer-by-layer assembly
2005
DJ Zhou, A Bruckbauer, C Abell, D Klenerman, DJ Kang
Advanced Materials
Aldosterone acts via an ATP autocrine/paracrine system: the Edelman ATP hypothesis revisited.
2005
J Gorelik, Y Zhang, D Sánchez, A Shevchuk, G Frolenkov, M Lab, D Klenerman, C Edwards, Y Korchev
Proceedings of the National Academy of Sciences of the United States of America
Individual Molecules of Dye-Labeled DNA Act as a Reversible Two-Color Switch upon Application of an Electric Field
2004
SS White, L Ying, S Balasubramanian, D Klenerman
Angewandte Chemie
Influence of the Foundation Layer on the Layer-by-Layer Assembly of Poly-l-lysine and Poly(styrenesulfonate) and Its Usage in the Fabrication of 3D Microscale Features
2004
D Zhou, A Bruckbauer, M Batchelor, D-J Kang, C Abell, D Klenerman
Langmuir
Measuring single-molecule nucleic acid dynamics in solution by two-color filtered ratiometric fluorescence correlation spectroscopy.
2004
H Li, X Ren, L Ying, S Balasubramanian, D Klenerman
Proceedings of the National Academy of Sciences of the United States of America
A simple voltage controlled enzymatic nanoreactor produced in the tip of a nanopipet
2004
A Bruckbauer, DJ Zhou, LM Ying, C Abell, D Klenerman
Nano Letters
Molecule by molecule direct and quantitative counting of antibody-protein complexes in solution
2004
H Li, D Zhou, H Browne, S Balasubramanian, D Klenerman
Analytical Chemistry
An addressable antibody nanoarray produced on a nanostructured surface.
2004
A Bruckbauer, D Zhou, D-J Kang, YE Korchev, C Abell, D Klenerman
Journal of the American Chemical Society
The use of scanning ion conductance microscopy to image A6 cells
2004
J Gorelik, Y Zhang, AI Shevchuk, GI Frolenkov, D Sánchez, MJ Lab, I Vodyanoy, CRW Edwards, D Klenerman, YE Korchev
Molecular and Cellular Endocrinology
Frequency and voltage dependence of the dielectrophoretic trapping of short lengths of DNA and dCTP in a nanopipette
2004
L Ying, SS White, A Bruckbauer, L Meadows, YE Korchev, D Klenerman
Biophys J
Evaluation of the effect of carbon dioxide corrosion inhibitors on cavitation damage caused during the ultrasound test
2004
AG Petersen, D Klenerman, WM Hedges
Corrosion
The use of scanning ion conductance microscopy to image A6 cells
2004
J Gorelik, Y Zhang, AI Shevchuk, GI Frolenkov, D Sánchez, MJ Lab, I Vodyanoy, CRW Edwards, D Klenerman, YE Korchev
Molecular and Cellular Endocrinology
Individual molecules of dye-labeled DNA act as a reversible two-color switch upon application of an electric field.
2004
SS White, L Ying, S Balasubramanian, D Klenerman
Angew Chem Int Ed Engl
Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer.
2003
LM Ying, JJ Green, HT Li, D Klenerman, S Balasubramanian
Proceedings of the National Academy of Sciences of the United States of America
Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer
2003
L Ying, JJ Green, H Li, D Klenerman, S Balasubramanian
Proc Natl Acad Sci U S A
Identification of a new RNA.RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenita point mutation.
2003
X Ren, G Gavory, H Li, L Ying, D Klenerman, S Balasubramanian
Nucleic acids research
Building Three-Dimensional Surface Biological Assemblies on the Nanometer Scale
2003
D Zhou, A Bruckbauer, LM Ying, C Abell, D Klenerman
Nano Letters
Multicomponent submicron features of biomolecules created by voltage controlled deposition from a nanopipet
2003
A Bruckbauer, D Zhou, L Ying, YE Korchev, C Abell, D Klenerman
Journal of the American Chemical Society
Dynamic assembly of surface structures in living cells.
2003
J Gorelik, AI Shevchuk, GI Frolenkov, IA Diakonov, MJ Lab, CJ Kros, GP Richardson, I Vodyanoy, CRW Edwards, D Klenerman, YE Korchev
Proceedings of the National Academy of Sciences
Vibrational spectroscopy of mechanically compressed monolayers.
2003
O Berg, D Klenerman
Journal of the American Chemical Society
Surface-sensitive molecular information on polymers from UV-resonance Raman spectroscopy.
2003
J-H Wang, D Klenerman, A van der Pol, RJ Meier
Appl Spectrosc
Kinetics of Unfolding the Human Telomeric DNA Quadruplex Using a PNA Trap
2003
JJ Green, L Ying, D Klenerman, S Balasubramanian
Journal of the American Chemical Society
Ultrasensitive coincidence fluorescence detection of single DNA molecules.
2003
H Li, L Ying, JJ Green, S Balasubramanian, D Klenerman
Analytical chemistry
A novel light source for SICM-SNOM of living cells.
2003
AM Rothery, J Gorelik, A Bruckbauer, W Yu, YE Korchev, D Klenerman
Journal of microscopy
Surface-sensitive molecular information on polymers from UV-resonance Raman spectroscopy
2003
JH Wang, D Klenerman, A Van Der Pol, RJ Meier
Applied Spectroscopy
Scanning surface confocal microscopy for simultaneous topographical and fluorescence imaging: Application to single virus-like particle entry into a cell
2002
J Gorelik, A Shevchuk, M Ramalho, M Elliott, C Lei, CF Higgins, MJ Lab, D Klenerman, N Krauzewicz, Y Korchev
Proceedings of the National Academy of Sciences
Ion channels in small cells and subcellular structures can be studied with a smart patch-clamp system.
2002
J Gorelik, Y Gu, HA Spohr, AI Shevchuk, MJ Lab, SE Harding, CRW Edwards, M Whitaker, GWJ Moss, DCH Benton, D Sánchez, A Darszon, I Vodyanoy, D Klenerman, YE Korchev
Biophys J
Writing with DNA and protein using a nanopipet for controlled delivery
2002
A Bruckbauer, L Ying, AM Rothery, D Zhou, AI Shevchuk, C Abell, YE Korchev, D Klenerman
J Am Chem Soc
Characterization of a Novel Light Source for Simultaneous Optical and Scanning Ion Conductance Microscopy
2002
A Bruckbauer, L Ying, AM Rothery, YE Korchev, D Klenerman
Anal Chem
High-resolution scanning patch-clamp: new insights into cell function
2002
Y Gu, J Gorelik, HA Spohr, A Shevchuk, MJ Lab, SE Harding, I Vodyanoy, D Klenerman, YE Korchev
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Programmable Delivery of DNA through a Nanopipet
2002
L Ying, A Bruckbauer, AM Rothery, YE Korchev, D Klenerman
Analytical chemistry
Effect of Cavitation on Carbon Dioxide Corrosion and the Development of a Test for Evaluating Inhibitors
2002
AG Petersen, D Klenerman, WM Hedges, ML Harris
Corrosion
A Sensitive and Economical Method to Directly Detect Particles
2002
MA Cooper, VP Ostanin, D Klenerman, A Slepstov, R Karamanska, FN Dultsev, K Stirrups, S Kelling, T Minson, C Abell
Proceedings of IEEE Sensors
Effects of mechanical compression on the vibrational spectrum of a self-assembled monolayer
2001
O Berg, D Klenerman
Journal of Applied Physics
Direct and sensitive detection of a human virus by rupture event scanning.
2001
MA Cooper, FN Dultsev, T Minson, VP Ostanin, C Abell, D Klenerman
Nature Biotechnology
Simultaneous Measurement of Ca2+ and Cellular Dynamics: Combined Scanning Ion Conductance and Optical Microscopy to Study Contracting Cardiac Myocytes
2001
AI Shevchuk, J Gorelik, SE Harding, MJ Lab, D Klenerman, YE Korchev
Biophys J
Direct and Quantitative Detection of Bacteriophage by “Hearing” Surface Detachment Using a Quartz Crystal Microbalance
2001
FN Dultsev, RE Speight, MT Fiorini, JM Blackburn, C Abell, VP Ostanin, D Klenerman
Analytical chemistry
Non-arrhenius kinetics for the loop closure of a DNA hairpin
2001
MI Wallace, L Ying, S Balasubramanian, D Klenerman
Proceedings of the National Academy of Sciences of the United States of America
Probing DNA surface attachment and local environment using single molecule spectroscopy
2001
MA Osborne, CL Barnes, S Balasubramanian, D Klenerman
The Journal of Physical Chemistry B
Two-state model of conformational fluctuation in a DNA hairpin-loop
2001
LM Ying, MI Wallace, D Klenerman
Chemical Physics Letters
FRET Fluctuation Spectroscopy: Exploring the Conformational Dynamics of a DNA Hairpin Loop
2000
MI Wallace, LM Ying, S Balasubramanian, D Klenerman
The Journal of Physical Chemistry B
In-situ studies of polycrystalline copper during methanol synthesis at high pressure using sum frequency generation at surfaces.
2000
SJ Lin, A Oldfield, D Klenerman
Surface Science
Single molecule analysis of DNA immobilized on microspheres
2000
MA Osborne, WS Furey, D Klenerman, S Balasubramanian
Anal Chem
Ratiometric Analysis of Single-Molecule Fluorescence Resonance Energy Transfer Using Logical Combinations of Threshold Criteria: A Study of 12-mer DNA
2000
LM Ying, MI Wallace, S Balasubramanian, D Klenerman
The Journal of Physical Chemistry B
“Hearing” Bond Breakage. Measurement of Bond Rupture Forces Using a Quartz Crystal Microbalance
2000
FN Dultsev, VP Ostanin, D Klenerman
Langmuir
Hybrid scanning ion conductance and scanning near-field optical microscopy for the study of living cells.
2000
YE Korchev, M Raval, MJ Lab, J Gorelik, CR Edwards, T Rayment, D Klenerman
Biophys J
Model corrosion inhibitor for in situ spectroscopic studies
2000
B Heeg, D Klenerman
Langmuir
Measurements of the Adsorption Kinetics of a Cationic Surfactant in a Liquid Jet by Ellipsometry
1999
J Hutchison, D Klenerman, S Manning-Benson, C Bain
Langmuir
Surface vibrational spectroscopy of lubricants adsorbed at the iron-water interface
1998
DC Duffy, A Friedmann, SA Boggis, D Klenerman
Langmuir
Persistency of corrosion inhibitor films on C-steel under multiphase flow conditions. Part II: optical SHG and electrochemical studies
1998
B Heeg, D Klenerman
Corrosion Science
Ultraviolet Resonance Raman Study of Drug Binding in Dihydrofolate Reductase, Gyrase, and Catechol O-Methyltransferase
1998
VW Couling, P Fischer, D Klenerman, W Huber
Biophysical journal
Persistency of corrosion inhibitor films on C-steel under multiphase flow conditions. Part I: the jet-cylinder arrangement
1998
B Heeg, T Moros, D Klenerman
Corrosion Science
Optically Biased Diffusion of Single Molecules Studied by Confocal Fluorescence Microscopy
1998
MA Osborne, S Balasubramanian, WS Furey, D Klenerman
The Journal of Physical Chemistry B
Optical chemical imaging of tobacco mosaic virus in solution at 60-nm resolution
1998
TH Keller, T Rayment, D Klenerman
Biophysical journal
Use of fluorescence resonance energy transfer to investigate the conformation of DNA substrates bound to the Klenow fragment.
1998
WS Furey, CM Joyce, MA Osborne, D Klenerman, JA Peliska, S Balasubramanian
Biochemistry
Scanning near-field optical microscopy in reflection mode imaging in liquid
1997
TH Keller, T Rayment, D Klenerman, RJ Stephenson
Review of Scientific Instruments
Ultraviolet resonance Raman spectroscopic study of the average environment of tyrosine in native and denatured barnase
1997
VW Couling, NW Foster, D Klenerman
Journal of Raman Spectroscopy
Mechanistic studies of the corrosion inhibitor oleic imidazoline
1994
A EDWARDS, C OSBORNE, S WEBSTER, D KLENERMAN, M JOSEPH, P OSTOVAR, M DOYLE
Corrosion Science
2ND-HARMONIC GENERATION AT SURFACES APPLIED TO CORROSION INHIBITION
1994
D KLENERMAN, J HODGE, M JOSEPH
Corrosion Science
Sum frequency spectra in the C-H stretch region of adsorbates on iron
1993
CR MAECHLING, DAV KLINER, D KLENERMAN
Applied Spectroscopy
A 2ND-HARMONIC GENERATION STUDY OF A CORROSION-INHIBITOR ON A MILD-STEEL ELECTRODE
1992
M JOSEPH, D KLENERMAN
Journal of Electroanalytical Chemistry
UV resonance Raman spectroscopy using a quasi–continuous—wave laser developed as an industrial analytical technique
1992
KPJ WILLIAMS, D KLENERMAN
Journal of Raman Spectroscopy
Multiplexed optically heterodyned Raman-induced Kerr-effect spectroscopy in the blue.
1991
D Klenerman
Opt Lett
Optically heterodyned Raman-induced Kerr-effect spectroscopy using a white-light continuum
1990
D KLENERMAN, DL GERRARD, H HERMAN, MT MACPHERSON
Chemical Physics Letters
Overtone spectra of C–H oscillators in cold molecules
1988
MW CROFTON, CG STEVENS, D KLENERMAN, JH GUTOW, RN ZARE
The Journal of Chemical Physics
Comparison of overtone-induced and electronic photochemistry of liquid tert-butyl hydroperoxide: supporting evidence for vibrational mode selectivity
1988
JH GUTOW, D KLENERMAN, RN ZARE
Journal of Physical Chemistry
Infrared chemiluminescence studies using a SISAM spectrometer. Reactions producing vibrationally excited OH
1987
D KLENERMAN, IWM SMITH
Journal of the Chemical Society, Faraday Transactions 2: Molecular and Chemical Physics
Infrared chemiluminescence using a SISAM spectrometer. Reactions producing vibrationally excited HF
1987
D KLENERMAN, IWM SMITH
Journal of the Chemical Society, Faraday Transactions 2
HOW EFFECTIVE IS INTERNAL EXCITATION IN PROMOTING THE HCL+1,3-BUTADIENE ADDITION-REACTION
1986
D KLENERMAN, RN ZARE
Chemical Physics Letters